VRK1 Polyclonal Antibody
SKU: E-AB-52422-200
VRK1 Polyclonal Antibody
| SKU # | E-AB-52422 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Applications | WB, IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Applications | WB, IHC |
| Clonality | Polyclonal |
| Immunogen | Fusion protein of human VRK1 |
| Abbre | VRK1 |
| Synonyms | MGC117401, MGC138280, MGC142070, PCH1, PCH1A, Serine/threonine protein kinase VRK1, Serine/threonine-protein kinase VRK1, VRK1, Vaccinia related kinase 1 , Vaccinia virus B1R related kinase 1, Vaccinia-related kinase 1 |
| Swissprot | |
| Calculated MW | 45 kDa |
| Observed MW | Refer to figures |
| Cellular Localization | Nucleus. Dispersed throughout the cell but not located on mitotic spindle or chromatids during mitosis. |
| Concentration | 0.5 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Research Areas | Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Signal transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1:2000 |
| IHC | 1:25-1:100 |
Background
This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases.This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas.Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination.This gene, therefore, may regulate cell proliferation.This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN.