UBA7 Polyclonal Antibody
SKU: E-AB-52436-200
UBA7 Polyclonal Antibody
| SKU # | E-AB-52436 |
| Reactivity | Human |
| Host | Rabbit |
| Applications | IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Fusion protein of human UBA7 |
| Abbre | UBA7 |
| Synonyms | D8, MGC12713, UBA1, UBA1B, UBA7, UBE 2, UBE1L, UBE2, Ube 1L, Ubiquitin Activating Enzyme E1 Like, Ubiquitin activa, Ubiquitin activating enzyme 2, Ubiquitin activating enzyme E1 homolog, ubiquitin activating enzyme E1, ubiquitin activating enzyme E1 homolog B |
| Swissprot | |
| Cellular Localization | Cytosol, Nucleus, nucleoplasm, Other locations: cytoplasm. |
| Concentration | 0.6 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Research Areas | Cancer, Cell Biology, Epigenetics and Nuclear Signaling |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| IHC | 1:30-1:150 |
Background
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein.