TP53 Polyclonal Antibody
SKU: E-AB-52130-200
TP53 Polyclonal Antibody
| SKU # | E-AB-52130 |
| Reactivity | Human |
| Host | Rabbit |
| Applications | WB |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | WB |
| Clonality | Polyclonal |
| Immunogen | Fusion protein of human TP53 |
| Abbre | TP53 |
| Synonyms | Antigen NY-CO-13, BCC7, Cellular tumor antigen p53, FLJ92943, LFS1, Mutant tumor protein 53, P53, Phosphoprotein p53, TRP53, Tp53, Transformation related protein 53, Tumor protein 53, Tumor protein p53, Tumor suppressor p53, p53, p53 tumor suppressor |
| Swissprot | |
| Calculated MW | 44 kDa |
| Observed MW | Refer to figures |
| Cellular Localization | Cytoplasm, Cytoplasm, Nucleus, Nucleus>PML body, Endoplasmic reticulum, Interaction with BANP promotes nuclear localization, Recruited into PML bodies together with CHEK2, Nucleus, Cytoplasm, Localized in both nucleus and cytoplasm in most cells, In some cells, forms foci in the nucleus that are different from nucleoli, Nucleus, Cytoplasm, Localized in the nucleus in most cells but found in the cytoplasm in some cells, Nucleus, Cytoplasm, Localized mainly in the nucleus with minor staining in the cytoplasm, Nucleus, Cytoplasm, Predominantly nuclear but localizes to the cytoplasm when expressed with isoform 4 and Nucleus, Cytoplasm, Predominantly nuclear but translocates to the cytoplasm following cell stress. |
| Concentration | 1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Research Areas | Cancer, Cell Biology, Epigenetics and Nuclear Signaling |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1:2000 |
Background
TP53,also named as P53 and NY-CO-13,belongs to the p53 family. It has 9 isoforms. In SDS-Page,the MW is about 53kd. TP53 acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. It is involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. The antibody reacts specifically with 53 kDa protein.