TCP1 Polyclonal Antibody Reactivity Human
SKU: E-AB-40159-200
TCP1 Polyclonal Antibody Reactivity Human
| SKU # | E-AB-40159 |
| Reactivity | Human |
| Host | Rabbit |
| Applications | WB |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | WB |
| Clonality | Polyclonal |
| Immunogen | Recombinant human T-complex protein 1 subunit alpha protein |
| Abbre | TCP1 |
| Synonyms | AI528772, CCT, CCT alpha, CCT-alpha, CCT1, CCTalpha, Ccta, D6S230E, MGC133746, T complex 1, T complex protein 1, T complex protein 1 alpha subunit, T-complex homolog TCP1, T-complex protein 1 subunit alpha, T-complex protein 1 subunit alpha B, Tailless complex, c-cpn, p63 |
| Swissprot | |
| Calculated MW | 60 kDa |
| Observed MW | 60 kDa |
| Cellular Localization | Cytoplasm. Cytoplasm>cytoskeleton>centrosome. |
| Concentration | 1 mg/mL |
| Buffer | PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4 |
| Purification Method | Antigen Affinity Purification |
| Research Areas | Cancer, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1:1000 |
| IHC | 1:50-1:100 |
Background
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, three pseudogenes that appear to be derived from this gene have been found.