Survivin Monoclonal Antibody
SKU: E-AB-22112-200
Survivin Monoclonal Antibody
| SKU # | E-AB-22112 |
| Reactivity | Human, Rat |
| Host | Mouse |
| Applications | WB, IHC-p |
Product Details
| Isotype | IgG |
| Host | Mouse |
| Reactivity | Human, Rat |
| Applications | WB, IHC-p |
| Clonality | Monoclonal |
| Immunogen | Recombinant Protein |
| Abbre | Survivin |
| Synonyms | API4, Apoptosis inhibitor 4, Apoptosis inhibitor survivin, Apoptosis inhibitor4, BIRC 5, BIRC5, Baculoviral IAP repeat containing 5, Baculoviral IAP repeat containing protein 5, Baculoviral IAP repeat-containing protein 5, EPR 1, IAP4, Survivin variant 3 alpha |
| Swissprot | |
| Observed MW | 16 kDa |
| Cellular Localization | Cytoplasm. Nucleus. Chromosome. Chromosome>centromere. Cytoplasm>cytoskeleton>spindle. Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalizes with AURKB at mitotic chromosomes. |
| Tissue Specificity | Expressed only in fetal kidney and liver, and to lesser extent, lung and brain. Abundantly expressed in adenocarcinoma (lung, pancreas, colon, breast, and prostate) and in high-grade lymphomas. Also expressed in various renal cell carcinoma cell lines. |
| Concentration | 1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol. |
| Purification Method | Protein A purification |
| Research Areas | Cancer, Cell Biology, Neuroscience |
| Clone No. | 4E2 |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:1000-2000 |
| IHC | 1:50-1:200 |
Background
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.