SETMAR Polyclonal Antibody Reactivity Human
SKU: E-AB-52907-200
SETMAR Polyclonal Antibody Reactivity Human
| SKU # | E-AB-52907 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Applications | IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Fusion protein of human SETMAR |
| Abbre | SETMAR |
| Synonyms | Histone lysine N methyltransferase, Histone lysine N methyltransferase SETMAR, Hsmar 1, Hsmar1, Mariner transposase Hsmar1, Metnase, SET domain and mariner transposase fusi, SET domain and mariner transposase fusion, SET domain and mariner transposase fusion gene |
| Swissprot | |
| Cellular Localization | Nucleus. Chromosome. |
| Concentration | 1.8 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Research Areas | Epigenetics and Nuclear Signaling |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| IHC | 1:50-1:300 |
Background
This gene encodes a fusion protein that contains an N-terminal histone-lysine N-methyltransferase domain and a C-terminal mariner transposase domain. The encoded protein binds DNA and functions in DNA repair activities including non-homologous end joining and double strand break repair. The SET domain portion of this protein specifically methylates histone H3 lysines 4 and 36. This gene exists as a fusion gene only in anthropoid primates, other organisms lack mariner transposase domain. Alternate splicing results in multiple transcript variants.