Recombinant Mouse TrkC/Ntrk3 (C-6His)
SKU: PKSM041444-50
Recombinant Mouse TrkC/Ntrk3 (C-6His)
| SKU # | PKSM041444 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | GP145-TrkC, NT-3 Growth Factor Receptor, Neurotrophic tyrosine kinase receptor type 3, TrkC, TrkC tyrosine kinase, trk-C |
| Species | Mouse |
| Expression Host | HEK293 Cells |
| Sequence | Cys32-Thr429 |
| Accession | Q6VNS1 |
| Calculated Molecular Weight | 45.5 kDa |
| Observed Molecular Weight | 80-110 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Three Trk family proteins, TrkA, TrkB, and TrkC, exhibiting different ligand specificities, have been identified. TrkA binds NGF and NT-3, TrkB binds BDNF, NT-3 and NT-4/5, and TrkC only binds NT-3. The primary location of TrkC expression is in the nervous system and, specifically, in regions of the CNS. Low level TrkC expression has also been observed in a wide variety of tissues outside the nervous system. Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.