Recombinant Mouse Nectin-4 (C-Fc)
SKU: PKSM041375-50
Recombinant Mouse Nectin-4 (C-Fc)
| SKU # | PKSM041375 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | Ig superfamily receptor LNIR, LNIR, Nectin-4, PRR4, PVRL4, Poliovirus receptor-related protein 4 |
| Species | Mouse |
| Expression Host | HEK293 Cells |
| Sequence | Gly31-Ser349 |
| Accession | Q8R007 |
| Calculated Molecular Weight | 61.4 kDa |
| Observed Molecular Weight | 75-85 kDa |
| Tag | C-Fc |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Nectin-4 (PVRL4) is a type I transmembrane glycoprotein that belongs to the nectin family within the immunoglobulin (Ig) superfamily. It contains two Ig-like C2-type domains and one Ig-like V-type domain. PVRL4 plays a role in cell adhesion through both trans-homophilic and heterophilic interactions, specifically interacting with nectin-1. However, it does not function as a receptor for alpha-herpesvirus entry into cells. This protein is primarily expressed in the placenta, embryo, and breast carcinoma but is not detected in normal breast epithelium. A soluble form of Nectin-4 is generated through proteolytic cleavage (shedding) at the cell surface, likely mediated by ADAM17. Mutations in the PVRL4 gene are responsible for ectodermal dysplasia-syndactyly syndrome type 1, a rare autosomal recessive disorder.