NF2 / Merlin Polyclonal Antibody
SKU: E-AB-40642-100
NF2 / Merlin Polyclonal Antibody
| SKU # | E-AB-40642 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Applications | WB |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| Clonality | Polyclonal |
| Immunogen | Recombinant Human NF2 protein expressed by E.coli. |
| Abbre | NF2 |
| Synonyms | ACN, BANF, Merlin, NF2, Neurofibromin 2, SCH, Schwannomerlin, Schwannomin, neurofibromin 2 (merlin) |
| Swissprot | |
| Calculated MW | 70 kDa |
| Observed MW | 66-70 kDa |
| Cellular Localization | Cell projection, filopodium membrane, Nucleus,Cytoplasm. |
| Concentration | 1 mg/mL |
| Buffer | PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4 |
| Purification Method | Antigen Affinity Purification |
| Research Areas | Cancer, Epigenetics and Nuclear Signaling, Neuroscience, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1:1000 |
Background
Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway,a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.