MSE PRO (R)-2-(2,5-Difluorophenyl)pyrrolidine, ≥97.0% Purity

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MSE PRO™ (R)-2-(2,5-Difluorophenyl)pyrrolidine, ≥97.0% Purity

MSE PRO™ (R)-2-(2,5-Difluorophenyl)pyrrolidine is a chiral pyrrolidine derivative containing two fluorine atoms on the phenyl ring and exists as the (R)-enantiomer. The presence of the fluorinated phenyl ring and the rigid pyrrolidine ring system make this compound a versatile synthetic intermediate for the preparation of various nitrogen-containing heterocyclic compounds and pharmaceutically active molecules. As a chiral building block, it can be employed in enantioselective synthesis, enabling the construction of optically pure drugs, agrochemicals, and other biologically active compounds where stereochemical purity is crucial for potency and selectivity.

MSE Supplies offers various N-heterocyclic drug small molecules and other chemical reagents. Please contact us for bulk orders.

Technical Specifications:

CAS No.	1218935-59-1
Chemical name	(R)-2-(2,5-Difluorophenyl)pyrrolidine
Synonym(s)	(2R)-2-(2,5-difluorophenyl)pyrrolidine
Molecular formula	C₁₀H₁₁F₂N
Pack size	1 g (CM1378)
Molecular weight	183.20 g/mol
Purity	≥97.0% (NMR)
Boiling point	213.5±40.0 °C (Predicted)
Density	1.164±0.06 g/mL (Predicted)
pKa	9.02±0.10 (Predicted)
Appearance	Light yellow to yellow liquid
Storage	2-8°C, protect from light

References:

[1] Cox, C. D., Coleman, P. J., Breslin, M. J., Whitman, D. B., Garbaccio, R. M., Fraley, M. E., ... & Hartman, G. D. (2008). Kinesin Spindle Protein (KSP) Inhibitors. 9. Discovery of (2 S)-4-(2, 5-Difluorophenyl)-N-[(3 R, 4 S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2, 5-dihydro-1 H-pyrrole-1-carboxamide (MK-0731) for the Treatment of Taxane-Refractory Cancer. Journal of medicinal chemistry, 51(14), 4239-4252.

[2] Chen, Q., Li, B. B., Zhang, L., Chen, X. R., Zhu, X. X., Chen, F. F., ... & Zheng, G. W. (2022). Engineered imine reductase for Larotrectinib intermediate manufacture. ACS Catalysis, 12(23), 14795-14803.