MSE PRO endo-tert-Butyl 8-azabicyclo[3.2.1]octan-3-ylcarbamate, ≥99.0% Purity - MSE Supplies LLC

MSE PRO endo-tert-Butyl 8-azabicyclo[3.2.1]octan-3-ylcarbamate, ≥99.0% Purity

SKU: CM1380

  • $ 20195
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MSE PRO™ endo-tert-Butyl 8-azabicyclo[3.2.1]octan-3-ylcarbamate, ≥99.0% Purity

MSE PRO™ endo-tert-Butyl 8-azabicyclo[3.2.1]octan-3-ylcarbamate is a derivative of 8-azabicyclo[3.2.1]octane, a bicyclic amine, with a tert-butyl carbamate group attached to the 3-position of the bicyclic ring system. The endo stereochemistry is crucial for controlling the spatial arrangement of substituents in the final product, allowing for the synthesis of complex and diverse molecular scaffolds. Moreover, the tert-butyl carbamate group serves as a protecting group, allowing for selective functionalization of the bicyclic amine while preserving the desired stereochemistry. This versatility enables the synthesis of complex drug-like molecules with improved drug-likeness, solubility, and metabolic stability.

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Technical Specifications:

Chemical name endo-tert-Butyl 8-azabicyclo[3.2.1]octan-3-ylcarbamate
  • endo-3-Boc-aminotropane
  • (3-endo)-8-Azabicyclo[3.2.1]oct-3-ylcarbamic acid tert-butyl ester
Molecular formula C12H22N2O2     
Pack size

1 g (CM1380)

Molecular weight 226.32 g/mol
Purity 99.81% (GC)
Boiling point    339.8±31.0 °C (Predicted) 
Density 1.07 g/mL
pKa 12.36±0.20 (Predicted)
Appearance White to off-white solid
Room temperature, protect from light


[1] Fang, Y., Yang, Z., Gundeti, S., Lee, J., & Park, H. (2017). Novel 5-nitropyrimidine derivatives bearing endo-azabicyclic alcohols/amines as potent GPR119 agonists. Bioorganic & Medicinal Chemistry25(1), 254-260.

[2] Kazmierski, W. M., Aquino, C., Chauder, B. A., Deanda, F., Ferris, R., Jones-Hertzog, D. K., ... & Youngman, M. (2008). Discovery of bioavailable 4, 4-disubstituted piperidines as potent ligands of the chemokine receptor 5 and inhibitors of the human immunodeficiency virus-1. Journal of medicinal chemistry51(20), 6538-6546.