MSE PRO Di-tert-butyl(2',4',6'-triisopropyl-3,6-dimethoxy-[1,1'-biphenyl]-2-yl)phosphine (tBuBrettphos), 98% Purity

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MSE PRO™ Di-tert-butyl(2',4',6'-triisopropyl-3,6-dimethoxy-[1,1'-biphenyl]-2-yl)phosphine (tBuBrettphos), 98% Purity

MSE PRO™ Di-tert-butyl(2',4',6'-triisopropyl-3,6-dimethoxy-[1,1'-biphenyl]-2-yl)phosphine (tBuBrettphos) is a highly efficient dialkylbiaryl phosphine ligand developed by the Buchwald group. It is renowned for its significant enhancement of cross-coupling reactions and reactivity in comparison to alternative catalytic systems. Notable examples of its effectiveness include its application in Pd-catalyzed conversion reactions of aryl and vinyl triflates, O-arylation of ethyl acetohydroximates, and conversion of aryl chlorides, triflates, and nonaflates to nitroaromatics.

MSE Supplies offers various catalysts and ligands of coupling reaction. Please contact us for customization or bulk orders.

Technical Specifications:

CAS No.	1160861-53-9
EINECS No.	811-756-3
Chemical name	Di-tert-butyl(2',4',6'-triisopropyl-3,6-dimethoxy-[1,1'-biphenyl]-2-yl)phosphine
Synonym(s)	tBuBrettPhos Di(tert-butyl)(2',4',6'-triisopropyl-3,6-dimethoxybiphenyl-2-yl)phosphine
Molecular formula	C₃₁H₄₉O₂P
Pack size	1 g (CM1317) 5 g (CM1318)
Molecular weight	484.7 g/mol
Purity	98 %
Melting point	166-170 °C
Appearance	White solid
Storage	Keep in Inert atmosphere, store at 2-8°C.

References:

[1] Gioria, E., Del Pozo, J., Martínez‐Ilarduya, J. M., & Espinet, P. (2016). Promoting difficult carbon–carbon couplings: which ligand does best?. Angewandte Chemie, 128(42), 13470-13474.

[2] Seo, T., Kubota, K., & Ito, H. (2020). Selective mechanochemical monoarylation of unbiased dibromoarenes by in situ crystallization. Journal of the American Chemical Society, 142(22), 9884-9889.