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MSE PRO cis-1-Boc-4-Amino-L-proline, ≥98.0% Purity– MSE Supplies LLC

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MSE PRO cis-1-Boc-4-Amino-L-proline, ≥98.0% Purity - MSE Supplies LLC

MSE PRO cis-1-Boc-4-Amino-L-proline, ≥98.0% Purity

SKU: CM1501

  • $ 25995
  • Save $ 3005

MSE PRO™ cis-1-Boc-4-Amino-L-proline, ≥98.0% Purity

MSE PRO™ cis-1-Boc-4-Amino-L-proline is a proline derivative that offers exceptional value in organic synthesis and medicinal chemistry applications. As a cis-substituted pyrrolidine, it possesses a unique rigid ring structure that can impart conformational constraints and influence the biological activity of target molecules. The strategic incorporation of the tert-butyloxycarbonyl (Boc) protecting group allows for selective deprotection, revealing a reactive primary amine functionality for further derivatization.

MSE Supplies offers various N-heterocyclic drug small molecules and other chemical reagents. Please contact us for bulk orders.

Technical Specifications:

CAS No. 132622-66-3
Chemical name cis-1-Boc-4-Amino-L-proline
Synonym(s)
  • (2S,4S)-1-Boc-4-Aminopyrrolidine-2-carboxylic acid
  • (2S,4S)-4-amino-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid
Molecular formula C10H18N2O4 
Pack size 5 g (CM1501)
Molecular weight 230.26 g/mol
Purity ≥98.0% (NMR)
Boiling point  371.1±42.0 °C (Predicted) 
Density   1.232 g/cm3 
pKa 3.65±0.20 (Predicted) 
Appearance Off-white to gray solid 
Storage  Store at room temperature, protect from light


References:

[1] de Gracia Retamosa, M., Ruiz‐Olalla, A., Agirre, M., de Cózar, A., Bello, T., & Cossío, F. P. (2021). Additive and emergent catalytic properties of dimeric unnatural amino acid derivatives: Aldol and conjugate additions. Chemistry–A European Journal, 27(63), 15671-15687.

[2] Ludwig, B. A., Forbes, C. R., & Zondlo, N. J. (2024). N-Terminal Proline Editing for the Synthesis of Peptides with Mercaptoproline and Selenoproline: Mechanistic Insights Lead to Greater Efficiency in Proline Native Chemical Ligation. ACS Chemical Biology, 19(2), 536-550.