MAP2K2 Monoclonal Antibody
SKU: E-AB-22162-200
MAP2K2 Monoclonal Antibody
| SKU # | E-AB-22162 |
| Reactivity | Human, Mouse, Rat |
| Host | Mouse |
| Applications | WB |
Product Details
| Isotype | IgG |
| Host | Mouse |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| Clonality | Monoclonal |
| Immunogen | Synthesized peptide derived from human MEK-2 around the non-phosphorylation site of T394. |
| Abbre | MEK2 |
| Synonyms | CFC syndrome, CFC4, Cardiofaciocutaneous syndrome, Dual specificity mitogen activated protein kinase kinase 2, Dual specificity mitogen-activated protein kinase kinase 2, ERK activator kinase 2, FLJ26075, MAP kinase kinase 2, MAPK / ERK kinase 2, MAPK/ERK k, map2k2 |
| Swissprot | |
| Observed MW | 45 kDa |
| Cellular Localization | Cytoskeleton, microtubule, Cytosol, Endoplasmic reticulum, endoplasmic reticulum, Endosome, early endosome, late endosome, Extracellular region or secreted, extracellular region, Golgi apparatus, Golgi apparatus, Mitochondrion, Nucleus, Peroxisome, peroxisomal membrane, Plasma Membrane, cytoplasmic side of Plasma Membrane, Other locations: cell-cell junction, focal adhesion, perinuclear region of cytoplasm. |
| Concentration | 1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol. |
| Purification Method | Protein A purification |
| Research Areas | Cancer, Signal Transduction |
| Clone No. | 2C3 |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1:2000 |
| IHC | 1:100-1:300 |
| IP | 1:200-1:500 |
Background
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.