KIF7 Monoclonal Antibody
SKU: E-AB-22026-200
KIF7 Monoclonal Antibody
| SKU # | E-AB-22026 |
| Reactivity | Human, Mouse, Rat |
| Host | Mouse |
| Applications | IHC-p, IF |
Product Details
| Isotype | IgG |
| Host | Mouse |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC-p, IF |
| Clonality | Monoclonal |
| Immunogen | Synthetic Peptide |
| Abbre | Kif 7 |
| Synonyms | EQYK340, KIF7, Kinesin-like protein kif7, UNQ340, kif7, kinesin family member 7, kinesin like protein KIF7 |
| Swissprot | |
| Cellular Localization | Cell projection>cilium. SMO is required for its accumulation within cilia. Moves from the cilia base to the cilia tip in response to activation of the Shh pathway. |
| Tissue Specificity | Embryonic stem cells, melanotic melanoma and Jurkat T-cells |
| Concentration | 1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol. |
| Purification Method | Protein A purification |
| Research Areas | Signal Transduction, Stem Cells |
| Clone No. | 3I4 |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| IHC | 1:100-1:300 |
| IF | 1:50-200 |
Background
This gene encodes a cilia-associated protein belonging to the kinesin family. This protein plays a role in the sonic hedgehog (SHH) signaling pathway through the regulation of GLI transcription factors. It functions as a negative regulator of the SHH pathway by preventing inappropriate activation of GLI2 in the absence of ligand, and as a positive regulator by preventing the processing of GLI3 into its repressor form. Mutations in this gene have been associated with various ciliopathies.KIF7 (Kinesin Family Member 7) is a Protein Coding gene. Diseases associated with KIF7 include Acrocallosal Syndrome and Hydrolethalus Syndrome 2. Among its related pathways are Signaling by Hedgehog and Signaling by GPCR. GO annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF27.