HMGCS1 Polyclonal Antibody Store at -20°C
SKU: E-AB-13295-200
HMGCS1 Polyclonal Antibody Store at -20°C
| SKU # | E-AB-13295 |
| Reactivity | Human |
| Host | Rabbit |
| Applications | WB, IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | WB, IHC |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human HMGCS1 |
| Abbre | HMGCS1 |
| Synonyms | 3 hydroxy 3 methylglutaryl Coenzyme A synthase 1 (soluble), 3-hydroxy-3-methylglutaryl coenzyme A synthase, EC 2.3.3.10, HMCS1, HMG CoA synthase, HMG-CoA synthase, HMGCS, HMGCS1, Hydroxymethylglutaryl CoA synthase, Hydroxymethylglutaryl-CoA, cytoplasmic |
| Swissprot | |
| Calculated MW | 57 kDa |
| Cellular Localization | Cytoplasm. |
| Concentration | 0.4 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Cardiovascular, Metabolism, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1:2000 |
| IHC | 1:50-1:200 |
Background
HMG-CoA Synthase exists as both a mitochondrial (mHMGCS) and cytoplasmic (cHMGCS) enzyme that condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The HMG-CoA produced by cHMGCS is transformed into mevalonate by HMG-CoA reductase, which starts isoprenoid biosynthesis. End products of the isoprenoid pathway include cholesterol, ubiquinone, dolichol, isopentenyl adenosine and farnesyl groups. mHMGCS, together with HMG-CoA Lyase, is responsible for ketone body biosynthesis. mHMGCS is expressed in liver and kidney. Fasting, cAMP and fatty acids increase the level of transcription of mHMGCS, while feeding and insulin repress it. A regulatory element within the mHMGCS promoter confers transcriptional regulation by PPAR, RXR, COUP-TF and HNF-4.