Histone H2B Monoclonal Antibody
SKU: E-AB-22086-200
Histone H2B Monoclonal Antibody
| SKU # | E-AB-22086 |
| Reactivity | Human, Mouse, Rat |
| Host | Mouse |
| Applications | WB, IF |
Product Details
| Isotype | IgG |
| Host | Mouse |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IF |
| Clonality | Monoclonal |
| Immunogen | Synthetic Peptide |
| Abbre | Histone H2B |
| Synonyms | (testis specific), H2B, H2B histone family, H2B histone family member U, H2B histone family member U testis specific, H2B testis, H2B1A, H2BFU, H2BT, H2ba, HIST1H2BA, Histone 1, Histone H2B, Histone H2B testi, Histone cluster 1 H2ba, bA317E16.3, member U, testis |
| Swissprot | |
| Calculated MW | 14 kDa |
| Observed MW | 14 kDa |
| Cellular Localization | Cytosol, Nucleus, nuclear chromosome, telomeric region, nucleoplasm, nucleus, Other locations: nucleosome. |
| Concentration | 1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol. |
| Purification Method | Protein A purification |
| Research Areas | Cancer, Epigenetics and Nuclear Signaling |
| Clone No. | 3C3 |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:1000-3000 |
| IF | 1:100-200 |
Background
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. HIST1H2BB (Histone Cluster 1 H2B Family Member B) is a Protein Coding gene. Among its related pathways are DNA Double-Strand Break Repair and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is HIST1H2BN.