GSK3 Alpha Polyclonal Antibody Store at -20°C
SKU: E-AB-15704-200
GSK3 Alpha Polyclonal Antibody Store at -20°C
| SKU # | E-AB-15704 |
| Reactivity | Human |
| Host | Rabbit |
| Applications | IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human GSK3A |
| Abbre | GSK3A |
| Synonyms | DKFZp686D0638, GSK 3 alpha, GSK 3A, GSK-3 alpha, GSK3A, GSK3alpha, Glycogen synthase kinase 3 alpha, Glycogen synthase kinase-3 alpha, Gsk3a, Serine/threonine protein kinase GSK3A |
| Swissprot | |
| Cellular Localization | Cytosol, Mitochondrion, Other locations: apical dendrite, beta-catenin destruction complex, neuronal cell body, postsynapse, proximal dendrite. |
| Concentration | 0.4 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Cell Biology, Cardiovascular, Signal Transduction, Stem Cells |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| IHC | 1:50-1:200 |
Background
This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth.