CYP2E1 Polyclonal Antibody Store at -20°C
SKU: E-AB-11118-200
CYP2E1 Polyclonal Antibody Store at -20°C
| SKU # | E-AB-11118 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Applications | WB, IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein of human CYP2E1 |
| Abbre | CYP2E1 |
| Synonyms | 4-nitrophenol 2-hydroxylase, CP2E1, CPE1, CYP2E, CYPIIE1, Cyp2e1, Cytochrome P, Cytochrome P450, Cytochrome P450 2E1, Cytochrome P450 LM3A, Cytochrome P450 isozyme 3A, cytochrome P450, family 2, polypeptide 1, subfamily IIE (ethanol-inducible), subfamily e |
| Swissprot | |
| Calculated MW | 57 kDa |
| Cellular Localization | Endoplasmic reticulum membrane. Microsome membrane. |
| Concentration | 0.5 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Cardiovascular, Metabolism, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1:2000 |
| IHC | 1:25-1:100 |
Background
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer.