CXCL12/SDF1 Polyclonal Antibody Reactivity Rat
SKU: E-AB-40578-200
CXCL12/SDF1 Polyclonal Antibody Reactivity Rat
| SKU # | E-AB-40578 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Applications | WB |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| Clonality | Polyclonal |
| Immunogen | Recombinant Rat CXCL12 protein expressed by E.coli. |
| Abbre | CXCL12 |
| Synonyms | SDF-1, Cxcl12 |
| Swissprot | |
| Calculated MW | 10 kDa |
| Observed MW | 10 kDa |
| Cellular Localization | Secreted |
| Concentration | 1 mg/mL |
| Buffer | PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4 |
| Purification Method | Antigen Affinity Purification |
| Research Areas | Immunology, Microbiology, Cardiovascular |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:2000-4000 |
Background
The stromal cell derived factor 1 (SDF1/CXCL12) is a small, pro-inflammatory chemoattractant cytokine that regulates leukocyte trafficking through interactions with its cognate 7-transmembrane G protein-coupled receptors. The SDF1/CXCL12 receptor, CXCR4, also serves as a coreceptor for the entry of human immunodeficiency virus into target cells. SDF1/CXCL12 may regulate homing and maintenance of CXCR4-expressing stem or progenitor cells, including embryonic and many somatic stem cells. Many cancer cells express CXCR4, suggesting that SDF1/CXCL12 plays a role in cancer metastasis. Alternative splicing and differential processing during maturation produce a pair of SDF1/CXCL12 isoforms (SDF1/CXCL12α and SDF1/CXCL12β) that have different properties and biological activities. Additional isoforms of SDF1/CXCL12 have been reported.