CRTAM Polyclonal Antibody
SKU: E-AB-10260-200
CRTAM Polyclonal Antibody
| SKU # | E-AB-10260 |
| Reactivity | Human |
| Host | Rabbit |
| Applications | WB, IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | WB, IHC |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein of human CRTAM |
| Abbre | CRTAM |
| Synonyms | CD355, CRTAM, Class I MHC restricted T cell associated molecule, Class-I MHC-restricted T-cell-associated molecule, Cytotoxic and regulatory T cell molecule, Cytotoxic and regulatory T-cell molecule |
| Swissprot | |
| Calculated MW | 45 kDa |
| Observed MW | Refer to Figures |
| Cellular Localization | Membrane. |
| Concentration | 0.3 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Immunology |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1:2000 |
| IHC | 1:50-1:200 |
Background
The CRTAM gene is upregulated in CD4 (see MIM 186940)-positive and CD8 (see CD8A; MIM 186910)-positive T cells and encodes a type I transmembrane protein with V and C1-like Ig domains. Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo.