CERS4 Polyclonal Antibody Store at -20°C
SKU: E-AB-13375-200
CERS4 Polyclonal Antibody Store at -20°C
| SKU # | E-AB-13375 |
| Reactivity | Human |
| Host | Rabbit |
| Applications | WB, IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | WB, IHC |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human CERS4 |
| Abbre | CERS4 |
| Synonyms | 4, CerS4, FLJ12089, LAG1, LAG1 homolog ceramide synthase 4, LAG1 longevity assurance homolog 4, LASS 4, LASS4, LASS4 LAG1 homolog ceramide synthase 4, S. cerevisiae, TRAM homolog 1, Trh 1, Trh1, ceramide synthase 4, homolog of |
| Swissprot | |
| Calculated MW | 46 kDa |
| Cellular Localization | Nucleus membrane. Endoplasmic reticulum membrane. |
| Concentration | 0.9 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Metabolism, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1:2000 |
| IHC | 1:50-1:200 |
Background
The LASS (longevity assurance homolog) family members are highly conserved from yeasts to mammals. Six members of this family of proteins have been characterized (LASS1, LASS2, LASS3, LASS4, LASS5 and LASS6) and they are all involved in sphingolipid synthesis. LASS4 is a 394 amino acid endoplasmic reticulum, multi-pass membrane protein. LASS4 increases the levels of long ceramides such as C22:0- and C24:0-ceramides. In cells deficient for CLN9, as observed in neuronal ceroid lipofuscinosis (NCL) or Batten disease, LASS4 can increase ceramide levels and partially correct growth and apoptosis.