BRCA2 Polyclonal Antibody Host Rabbit
SKU: E-AB-40288-200
BRCA2 Polyclonal Antibody Host Rabbit
| SKU # | E-AB-40276 |
| Reactivity | Human, Rat |
| Host | Rabbit |
| Applications | WB, IHC, IF |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Rat |
| Applications | WB, IHC, IF |
| Clonality | Polyclonal |
| Immunogen | Recombinant Human Breast cancer type 2 susceptibility protein |
| Abbre | BRCA2 |
| Synonyms | BRCC 2, BROVCA2, Breast and ovarian cancer susceptibility gene early onset antibody, FACD, FAD 1, FANCB, GLM3, BRCA 2 |
| Swissprot | |
| Calculated MW | 384 kDa |
| Observed MW | 384 kDa |
| Cellular Localization | Nucleus, Cytoskeleton. |
| Concentration | 1 mg/mL |
| Buffer | PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4 |
| Purification Method | Antigen Affinity Purification |
| Research Areas | Cancer, Epigenetics and Nuclear Signaling |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:1000-1:3000 |
| IHC | 1:100-1:200 |
| IF | 1:100-1:400 |
Background
Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele.