ACTN1 Monoclonal Antibody
SKU: E-AB-22127-200
ACTN1 Monoclonal Antibody
| SKU # | E-AB-22127 |
| Reactivity | Human, Mouse, Rat |
| Host | Mouse |
| Applications | IHC-p |
Product Details
| Isotype | IgG |
| Host | Mouse |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC-p |
| Clonality | Monoclonal |
| Immunogen | Recombinant Protein of a-actinin of ACTN1 |
| Abbre | ACTN1 |
| Synonyms | ACTN 1, ACTN1, Actinin alpha 1, Actn1, Alpha Actinin 1, Alpha actinin cytoskeletal isoform, Alpha-actinin cytoskeletal isoform, Alpha-actinin-1, BDPLT15, F, F actin cross linking protein, F-actin cross-linking protein, FLJ40884, actinin, actinin 1 smooth muscle, alpha 1 |
| Swissprot | |
| Cellular Localization | Cytoplasm>cytoskeleton. Cytoplasm>myofibril>sarcomere>Z line. Colocalizes with MYOZ2 and PPP3CA at the Z-line of heart and skeletal muscle. |
| Concentration | 1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol. |
| Purification Method | Protein A purification |
| Research Areas | Cancer, Developmental Biology, Signal Transduction, Stem Cells |
| Clone No. | 1D4 |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| IHC | 1:100-200 |
Background
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene.