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MSE PRO 6-Chloro-1H,2H,3H-pyrrolo[2,3-b]pyridin-2-one, ≥97.0% Purity - MSE Supplies LLC

MSE PRO 6-Chloro-1H,2H,3H-pyrrolo[2,3-b]pyridin-2-one, ≥97.0% Purity

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MSE PRO™ 6-Chloro-1H,2H,3H-pyrrolo[2,3-b]pyridin-2-one, ≥97.0% Purity

MSE PRO™ 6-Chloro-1H,2H,3H-pyrrolo[2,3-b]pyridin-2-one is a versatile heterocyclic building block with a pyrrolo[2,3-b]pyridine scaffold, which is a privileged structure in medicinal chemistry. This makes it a valuable precursor for synthesizing a wide range of biologically active compounds. The chloro substituent at the 6-position provides an excellent handle for further functionalization via cross-coupling reactions, allowing you to easily introduce diverse substituents and access a library of derivatives.

MSE Supplies offers various N-heterocyclic drug small molecules and other chemical reagents. Please contact us for bulk orders.

Technical Specifications:

CAS No. 220896-14-0
Chemical name 6-Chloro-1H,2H,3H-pyrrolo[2,3-b]pyridin-2-one
Synonym(s)

  • 6-chloro-1H-pyrrolo[2,3-b]pyridin-2(3H)-one

  • 6-Chloro-7-aza-2-oxindole
Molecular formula C7H5ClN2O          
Pack size

5 g (CM1372)
Molecular weight 168.58 g/mol
Purity ≥97.0% (NMR)
Boiling point  331.9±52.0 °C (Predicted)
Density  1.61±0.1 g/mL (Predicted)
Appearance Purple to pink solid
Storage  Store at room temperature


References:

[1] Abdel-Maksoud, M. S., Ali, E. M., Ammar, U. M., Mersal, K. I., Yoo, K. H., & Oh, C. H. (2020). Design and synthesis of novel pyrrolo [2, 3-b] pyridine derivatives targeting V600EBRAF. Bioorganic & Medicinal Chemistry, 28(11), 115493.

[2] Carbone, A., Pennati, M., Parrino, B., Lopergolo, A., Barraja, P., Montalbano, A., ... & Zaffaroni, N. (2013). Novel 1 H-pyrrolo [2, 3-b] pyridine derivative nortopsentin analogues: Synthesis and antitumor activity in peritoneal mesothelioma experimental models. Journal of Medicinal Chemistry, 56(17), 7060-7072.