MSE PRO 3,3-Difluoropyrrolidine hydrochloride, ≥97.0% Purity

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MSE PRO™ 3,3-Difluoropyrrolidine hydrochloride, ≥97.0% Purity

MSE PRO™ 3,3-Difluoropyrrolidine hydrochloride is a pyrrolidine salt containing fluorine, with the amine group protonated by hydrochloric acid, imparting unique structural and property characteristics. The presence of two fluorine atoms on the pyrrolidine ring makes this compound a valuable building block for the synthesis of fluorinated heterocycles and pharmaceutically active compounds, as fluorination can modulate the physicochemical and biological properties of drug candidates.

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Technical Specifications:

CAS No.	163457-23-6
Chemical name	3,3-Difluoropyrrolidine hydrochloride
Synonym(s)	3,3-Difluoropyrrolidine HCl cis-1-Methyl-2-oxo-1,2-dihydro-quinoline-5-carboxylic acid
Molecular formula	C₄H₈ClF₂N
Pack size	100 g (CM1379)
Molecular weight	143.56 g/mol
Purity	≥97.0% (NMR)
Melting point	128-130 °C
Appearance	White to off-white solid
Storage	2-8°C, sealed storage, away from moisture

References:

[1] Caldwell, C. G., Chen, P., He, J., Parmee, E. R., Leiting, B., Marsilio, F., ... & Weber, A. E. (2004). Fluoropyrrolidine amides as dipeptidyl peptidase IV inhibitors. Bioorganic & medicinal chemistry letters, 14(5), 1265-1268.

[2] Wei, L., Makowski, T. M., & Rutherford, J. L. (2012). An efficient synthesis of 3, 3-difluoro-pyrrolidine hydrochloride starting with 2-chloro-2, 2-difluoroacetic acid. Journal of Fluorine Chemistry, 135, 354-357.