ZNF354A Polyclonal Antibody Reactivity Human
SKU: E-AB-52385-200
ZNF354A Polyclonal Antibody Reactivity Human
| SKU # | E-AB-52385 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Applications | IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Fusion protein of human ZNF354A |
| Abbre | ZNF354A |
| Synonyms | and developmentally regulated protein 1, ischemia, EZNF, HKL1, HLK1, Homo sapiens zinc finger protein 354A, KID 1, KID1, Kidney, Renal transcription factor Kid 1 , TCF-17, TCF17, Transcription factor 17, Z354A, ZNF354, Zinc finger protein 354A, Zinc finger protein eZNF |
| Swissprot | |
| Cellular Localization | Nucleus. |
| Concentration | 0.5 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Research Areas | Epigenetics and Nuclear Signaling, Neuroscience |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| IHC | 1:30-1:150 |
Background
ZNF354A, also called EZNF, KID-1 or TCF17, belongs to the Krüppel C2H2-type zinc-finger family of proteins that contain KRAB domains and act as transcriptional regulators. Expressed primarily in the adult kidney, ZNF354A is a transcriptional repressor that plays a role in late renal development and is suppressed after renal ischemia. The N-terminus of ZNF354A contains the KRAB domain which confers transcriptional repressor activity, while the C-terminus contains multiple Cys2His2-zinc fingers. ZNF354A is located in the nucleolus and is thought to specifically influence development of the proximal tubule by shutting off dispensable or inhibitory genes. Reduced ZNF354A expression prevents proper cell differentiation and may, therefore, be implicated in renal carcinoma.