VE-Cadherin Polyclonal Antibody
SKU: E-AB-12772-200
VE-Cadherin Polyclonal Antibody
| SKU # | E-AB-12772 |
| Reactivity | Human |
| Host | Rabbit |
| Applications | IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human CDH5 |
| Abbre | CDH5 |
| Synonyms | 1, 7B 4, 7B4, 7B4 antigen, CADH5, CD 144, CD144, CD144 anti, Cadherin 5, Cadherin 5 type 2, Cadherin-5, Cadherin5, VE cadherin (vascular epithelium), cadherin, type 2, type 2 (vascular endothelium), vascular endothelial |
| Swissprot | |
| Cellular Localization | Cell junction. Cell membrane. Found at cell-cell boundaries and probably at cell-matrix boundaries. |
| Concentration | 0.4 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Cardiovascular, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| IHC | 1:50-1:200 |
Background
This gene is a classical cadherin from the cadherin superfamily and is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but its full length sequence has not been determined.