TONSL Polyclonal Antibody Store at -20°C
SKU: E-AB-10088-200
TONSL Polyclonal Antibody Store at -20°C
| SKU # | E-AB-10088 |
| Reactivity | Human |
| Host | Rabbit |
| Applications | IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein of human TONSL |
| Abbre | TONSL |
| Synonyms | I kappa B related protein, I-kappa-B-related protein, IKBR, IkappaBR, Inhibitor of kappa B related protein, Inhibitor of kappa B-related protein, MMS22L-interacting protein, NF kappa B inhibitor like protein 2, NF-kappa-B i, NFBIL2/TONSL |
| Swissprot | |
| Cellular Localization | Cytoplasm. Nucleus. Mainly nuclear. Localizes to DNA damage sites, accumulates at stressed replication forks. |
| Concentration | 0.6 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Epigenetics and Nuclear Signaling, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| IHC | 1:100-1:300 |
Background
The protein encoded by this gene is thought to be a negative regulator of NF-kappa-B mediated transcription.The encoded protein may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA.Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus.