SRGAP3 Polyclonal Antibody
SKU: E-AB-11600-200
SRGAP3 Polyclonal Antibody
| SKU # | E-AB-11600 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Applications | IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein of human SRGAP3 |
| Abbre | SRGAP3 |
| Synonyms | ARHGAP 14, ARHGAP14, Gbi, ME GAP, MEGAP, Mental disorder associated GAP, Mental disorder-associated GAP, Rho GTPase activating protein 14, Rho GTPase-activating protein 14, SLIT ROBO Rho GTPase activating protein 3, SLIT-ROBO Rho GTPase-activating protein 3, srGAP 2 |
| Swissprot | |
| Cellular Localization | Cytosol, Other locations: cytoplasm. |
| Concentration | 0.6 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Neuroscience, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| IHC | 1:25-1:100 |
Background
SRGAP3 is a 1099 amino acid protein containing 1 FCH domain, 1 Rho-GAP domain and 1 SH3 domain. Expressed highly in brain, and in lower levels in kidney, WRP is thought to play a role in cell migration through its interaction with Cdc42 and Rac1. Cdc42 and Rac1 are two intracellular signaling proteins that regulate the multistep cell migration process. WRP downregulates Cdc42 and Rac1 activity, thereby impairing actin and microtubule dynamics, the formation of protrusions, and total cell migration. Defects in the gene encoding WRP have been linked to severe idiopathic mental retardation. Three isoforms of WRP exist as a result of alternative splicing events.