PIAS2 Polyclonal Antibody
SKU: E-AB-13005-200
PIAS2 Polyclonal Antibody
| SKU # | E-AB-13005 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Applications | IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human PIAS2 |
| Abbre | PIAS2 |
| Synonyms | ARIP3, Androgen receptor interacting protein 3, Androgen receptor-interacting protein 3, DAB2 interacting protein, DAB2-interacting protein, DIP, E3 SUMO protein ligase PIAS2, E3 SUMO-protein ligase PIAS2, MIZ, Miz1, Msx interacting zinc finger protein, Msx-interact |
| Swissprot | |
| Cellular Localization | Nucleus speckle. Nucleus, PML body. Nucleus. Colocalizes at least partially with promyelocytic leukemia nuclear bodies (PML NBs) (PubMed:22406621). Colocalizes with SUMO1 in nuclear granules (By similarity). |
| Concentration | 0.6 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cell Biology, Epigenetics and Nuclear Signaling |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| IHC | 1:50-1:200 |
Background
This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family.PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins.Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor.A pseudogene of this gene is located on the short arm of chromosome 4.The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1.