PDX1 Polyclonal Antibody Store at -20°C
SKU: E-AB-15824-200
PDX1 Polyclonal Antibody Store at -20°C
| SKU # | E-AB-15824 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Applications | WB, IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human PDX1 |
| Abbre | PDX1 |
| Synonyms | GSF, Glucose sensitive factor, Glucose-sensitive factor, IDX 1, IDX-1, IDX1, IPF 1, IPF-1, IPF1, IUF , Insulin promoter factor 1, Insulin promoter factor 1 homeodomain transcription factor, Insulin upstream factor 1, Islet/duodenum homeobox 1, Islet/duodenum homeobox-1 |
| Swissprot | |
| Calculated MW | 31 kDa |
| Cellular Localization | Nucleus. |
| Concentration | 0.4 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Metabolism, Developmental Biology, Signal Transduction, Stem Cells |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1:2000 |
| IHC | 1:15-1:50 |
Background
The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).