LIMS1 Polyclonal Antibody
SKU: E-AB-11365-200
LIMS1 Polyclonal Antibody
| SKU # | E-AB-11365 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Applications | WB, IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Applications | WB, IHC |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein of human LIMS1 |
| Abbre | LIMS1 |
| Synonyms | 2310016J22Rik, 4921524A02Rik, AI507642, AU021743, AW551584, C430041B13Rik, LIM, LIM and senescent cell antigen like domains 1, LIM and senescent cell antigen-like-containing domain protein 1, LIM zinc finger domain containing 1, LIM-type zinc finger domains 1, Lims1 |
| Swissprot | |
| Calculated MW | 37 kDa |
| Cellular Localization | Cell junction>focal adhesion. Cell membrane. |
| Concentration | 0.2 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Cardiovascular, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1:2000 |
| IHC | 1:50-1:200 |
Background
The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene.