KPNB1 Polyclonal Antibody
SKU: E-AB-13334-200
KPNB1 Polyclonal Antibody
| SKU # | E-AB-13334 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Applications | IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human KPNB1 |
| Abbre | KPNB1 |
| Synonyms | IMB 1, IMB1, IPOB, Impnb, Importin 90, Importin beta 1, Importin beta 1 subunit, Importin subunit beta-1, Importin-90, KPNB 1, Karyopherin beta 1, Karyopherin beta 1 subunit, Karyopherin subunit beta-1, Kpnb1, MGC2155, MGC2156, MGC2157, NTF 97, NTF97, Nuclear factor P9 |
| Swissprot | |
| Cellular Localization | Cytoplasm. Nucleus envelope. |
| Concentration | 1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Epigenetics and Nuclear Signaling, Signal Transduction, Tags and Cell Markers |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| IHC | 1:50-1:200 |
Background
Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore.