KCNA1 Polyclonal Antibody Store at -20°C
SKU: E-AB-15740-200
KCNA1 Polyclonal Antibody Store at -20°C
| SKU # | E-AB-15740 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Applications | WB, IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human KCNA1 |
| Abbre | KCNA1 |
| Synonyms | AEMK, EA1, Episodic ataxia with myokymia, HBK1, HUK1, KCNA1, KV1.1, Kca1 1, Kcna1, Kcpvd, MBK1, MGC124402, MGC126782, MGC138385, MK1, Potassium, Potassium channel protein 1, Potassium voltage gated channel shaker related subfamily member 1, homolog of KV1.1, mceph, mouse |
| Swissprot | |
| Calculated MW | 56 kDa |
| Cellular Localization | Membrane. |
| Concentration | 0.3 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Neuroscience |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1:2000 |
| IHC | 1:15-1:50 |
Background
This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. The encoded protein has six putative transmembrane segments (S1-S6), and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif (GYGD). The functional channel is a homotetramer. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. Mutations in this gene have been associated with myokymia with periodic ataxia (AEMK).