GNRHR Polyclonal Antibody Store at -20°C
SKU: E-AB-12492-200
GNRHR Polyclonal Antibody Store at -20°C
| SKU # | E-AB-12492 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Applications | WB |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Applications | WB |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human GNRHR |
| Abbre | GNRHR |
| Synonyms | GNRHR, GNRHR1, GRHR, GnRH receptor, GnRH-R, Gonadotropin releasing hormone receptor, Gonadotropin-releasing hormone receptor, HH7, LHRHR, LRHR, gonadotropin-releasing hormone (type 1) receptor 1, leutinizing-releasing hormone receptor, lh-rh, luliberin receptor |
| Swissprot | |
| Calculated MW | 28 kDa |
| Cellular Localization | Plasma Membrane, integral component of Plasma Membrane, Other locations: membrane. |
| Concentration | 0.3 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Neuroscience |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1:2000 |
Background
This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene.