FLNA Polyclonal Antibody Store at -20°C
SKU: E-AB-11240-200
FLNA Polyclonal Antibody Store at -20°C
| SKU # | E-AB-11240 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Applications | WB, IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Applications | WB, IHC |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein of human FLNA |
| Abbre | FLNA |
| Synonyms | ABP 280, ABP-280, APBX, Actin-binding protein 280, Alpha filamin, Alpha-filamin, CSBS, CVD1, Endothelial actin binding protein, Endothelial actin-binding protein, FLN, FLN-A, FLN1, FLNA, FMD, Filamin 1, Filamin A, Filamin A alpha, Filamin-1, Filamin-A, MNS, NHBP, Non musc |
| Swissprot | |
| Calculated MW | 281 kDa |
| Cellular Localization | Cytoplasm>cell cortex. Cytoplasm>cytoskeleton. |
| Concentration | 0.6 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1:2000 |
| IHC | 1:50-1:200 |
Background
The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.