ERK1/2 Polyclonal Antibody
SKU: E-AB-12397-200
ERK1/2 Polyclonal Antibody
| SKU # | E-AB-12397 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Applications | WB, IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human MAPK1/MAPK3 |
| Abbre | ERK1/2 |
| Synonyms | ERK1, ERK1/2, ERK2 |
| Swissprot | |
| Calculated MW | 41/43 kDa |
| Cellular Localization | Cytoskeleton, Cytosol, Endosome, early endosome, late endosome, Extracellular region or secreted, extracellular exosome, Golgi apparatus, Golgi apparatus, Mitochondrion, Nucleus, nuclear envelope, nucleoplasm, nucleus, Plasma Membrane, caveola, plasma membrane, Other locations: cytoplasm, focal adhesion, protein complex, pseudopodium. |
| Concentration | 0.5 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Neuroscience, Signal Transduction, Stem Cells |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1:2000 |
| IHC | 1:50-1:200 |
Background
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.