DAB2 Polyclonal Antibody Store at -20°C
SKU: E-AB-14925-200
DAB2 Polyclonal Antibody Store at -20°C
| SKU # | E-AB-14925 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Applications | WB, IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein of human DAB2 |
| Abbre | DAB2 |
| Synonyms | DAB 2, DAB2, Dab, Differentially expressed in ovarian cancer 2, Differentially expressed protein 2, Disabled (Drosophila) homolog 2 (mitogen responsive phosphoprotein), Disabled homolog, Disabled homolog 2, homolog 2 (Drosophila), mitogen-responsive phosphoprotein |
| Swissprot | |
| Calculated MW | 82 kDa |
| Cellular Localization | Cytoplasmic vesicle, clathrin coated vesicle, clathrin coated vesicle membrane, Cell membrane, coated pit, clathrin coated pit, Note: Colocalizes with large insert containing isoforms of MYO6 at clathrin coated pits/vesicles. |
| Concentration | 0.6 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Epigenetics and Nuclear Signaling, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1:2000 |
| IHC | 1:50-1:200 |
Background
This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.