ADRA1B Polyclonal Antibody Store at -20°C
SKU: E-AB-12279-200
ADRA1B Polyclonal Antibody Store at -20°C
| SKU # | E-AB-12279 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Applications | WB |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human ADRA1B |
| Abbre | ADRA1B |
| Synonyms | ADA1B, ADRA 1, ADRA1, ADRA1B, Adra 1b, Adrenergic alpha 1B receptor, Adrenergic receptor alpha 1b, Adrenoceptor alpha 1B, Alpha 1 adrenergic receptor, Alpha 1B adrenoceptor, Alpha 1B adrenoreceptor, Alpha-1B adrenergic receptor, Alpha-1B adreno, Alpha-1B adrenoceptor |
| Swissprot | |
| Calculated MW | 57 kDa |
| Cellular Localization | Nucleus membrane. Cell membrane. Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes. |
| Concentration | 0.3 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Neuroscience |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:200-1:1000 |
Background
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region.