MSE PRO™ [2',4'-Bis(1,1-dimethylethyl)-6'-methoxy[1,1'-biphenyl]-2-yl]dicyclohexylphosphine (VPhos), 98% Purity

MSE PRO™ [2',4'-Bis(1,1-dimethylethyl)-6'-methoxy[1,1'-biphenyl]-2-yl]dicyclohexylphosphine (VPhos) was developed as a hybrid ligand incorporating structural elements of existing ligands for improved activity in the micelle-enhanced palladium-catalyzed cross-coupling of non-aromatic O- and N-heterocyclic alkyl bromides with (hetero)aryl halides. The Pd/VPhos catalyst (5 mol %) and a simple surfactant system based on octanoic acid enabled the efficient synthesis of a broad range of alkylated (hetero)arenes.

MSE Supplies offers various catalysts and ligands of coupling reaction. Please contact us for customization or bulk orders.

Technical Specifications:

CAS No.	1848244-75-6
Chemical name	[2',4'-Bis(1,1-dimethylethyl)-6'-methoxy[1,1'-biphenyl]-2-yl]dicyclohexylphosphine
Synonym(s)	VPhos Dicyclohexyl(2',4'-di-tert-butyl-6'-methoxy-[1,1'-biphenyl]-2-yl)phosphane
Molecular formula	C₃₃H₄₉OP
Pack size	1 g (CM1339) 5 g (CM1340)
Molecular weight	492.72 g/mol
Purity	98 %
Melting point	113-118 °C
Appearance	White to off-white solid
Storage	-20°C, stored under nitrogen

References:

[1] Bhonde, V. R., O'Neill, B. T., & Buchwald, S. L. (2016). An Improved System for the Aqueous Lipshutz–Negishi Cross‐Coupling of Alkyl Halides with Aryl Electrophiles. Angewandte Chemie, 128(5), 1881-1885.

[2] Knochel, P., & Haas, D. (2016). Palladacycle-Catalyzed Aqueous Lipshutz–Negishi Cross-Coupling. Synfacts, 12(03), 0299-0299.

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