AFP Polyclonal Antibody

SKU #	E-AB-10000
Reactivity	H
Host	Rabbit
Applications	WB, IHC, ELISA

Test Application

Verified Samples

Reactivity	Application
Human	WB (liver)
Mouse	IHC (kidney)

Dilution: WB,,1:1000-1:5000;IHC,,1:50-1:200;

Product Details

Clonality	Polyclonal
Isotype	IgG
Concentration	0.5 mg/mL
Storage	Store at -20℃. Avoid freeze / thaw cycles.
Buffer	PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Purification Method	Affinity purification
Research Areas	Cancer, Cardiovascular, Developmental Biology
Conjugation	Unconjugated

Immunogen Details

Immunogen	Recombinant protein of human AFP
Abbre	AFP
Synonyms	Afp,AFPD,Alpha fetoglobulin,Alpha fetoprotein,Alpha fetoprotein precursor,Alpha-1-fetoprotein,Alpha-fetoglobulin,Alpha-fetoprotein,alpha-fetoprotein,Hereditary persistence of,included,FETA,FETA,Hereditary persistence of alpha fetoprotein,HPAFP
Swissprot	P02771
Gene Accession	BC027881
Calculated MW	69kDa
Cellular Localization	Secreted.
Tissue Specificity	Plasma. Synthesized by the fetal liver and yolk sac.

Related Reagents

Application	Products
WB	Western Blot Detection Kit(E-IR-R304)
IHC	2-step plus Poly-HRP Anti Mouse/Rabbit IgG Detection System (with DAB solution)(E-IR-R217)

Background

This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly.

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