Tribioscience LDN193189 HCl, ALK 2, 3 Inhibitor (TBI4764)

Tribioscience LDN193189 HCl, ALK 2, 3 Inhibitor (TBI4764)

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Product Details

Formal Name: 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline, dihydrochloride

Alternate Names: DM-3189

Molecular Formula: C₂₅H₂₂N₆·2HCl

Formula Weight: 479.40

CAS Number: 1062368-62-0

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO or in Water (up to 5 mg/ml)

Storage: -20°C

Stability: ≥ 1 year.

Applications

ALK 2, 3 inhibitor

Functions

LDN-193189 HCl is a potent and selective inhibitor of ALK2 (IC50 = 5 nM) and ALK3 (IC50 = 30 nM), thereby inhibiting SMAD1/5/8 phosphorylation. Only weak inhibition of ALK4, ALK5, and ALK7 is observed.  Promotes neuronal differentiation of human pluripotent stem cells. LDN-193189 HCl has also been used to examine the role of osteogenesis in prostate tumor metastases in bone.

Application Procedures

First dissolved in DMSO or in Water (up to 5 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or distilled water may be stored at -20°C for up to 2 months.