Recombinant Rat UNC5B/UNC5H2 Protein (Fc Tag)
SKU: PKSR030375-100
Recombinant Rat UNC5B/UNC5H2 Protein (Fc Tag)
| SKU # | PKSR030375 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | UNC5B |
| Species | Rat |
| Expression Host | HEK293 Cells |
| Sequence | Met1-Asp373 |
| Accession | NP_071543.1 |
| Calculated Molecular Weight | 65.7 kDa |
| Observed Molecular Weight | 72-90 kDa |
| Tag | C-hFc |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 85 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4 Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
The netrin-1 receptor, UNC-5 Homology B, or UNC5B plays vital roles in angiogenesis, inflammation, embryonic development and carcinogenesis. Overexpression of UNC5B human colon epithelial cells suppressed dextran sodium sulfate, or DSS-induced apoptosis and caspase-3 activity. In addition, is a potential anti-neoplastic target in bladder cancer progression and inflammatory arthritis.