PI 3 Kinase p85 Alpha Monoclonal Antibody
SKU: E-AB-22164-200
PI 3 Kinase p85 Alpha Monoclonal Antibody
| SKU # | E-AB-22164 |
| Reactivity | Mouse, Rat |
| Host | Mouse |
| Applications | WB, IHC-p |
Product Details
| Isotype | IgG |
| Host | Mouse |
| Reactivity | Mouse, Rat |
| Applications | WB, IHC-p |
| Clonality | Monoclonal |
| Immunogen | Recombinant Protein |
| Abbre | PI3 Kinase P85α |
| Synonyms | GRB1, P85A, Phosphatidylinositol 3 kinase, Phosphatidylinositol 3 kinase associated p 85 alpha, Phosphatidylinositol 3 kinase regulatory 1, Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha, p85, p85 alpha, polypeptide 1 (p85 alpha), regulatory subunit |
| Swissprot | |
| Observed MW | 85 kDa |
| Cellular Localization | Cytosol, Endoplasmic reticulum, perinuclear endoplasmic reticulum membrane, Nucleus, Plasma Membrane, Other locations: cell-cell junction, cis-Golgi network, cytoplasm, membrane, phosphatidylinositol 3-kinase complex, phosphatidylinositol 3-kinase complex, class IA, protein complex. |
| Tissue Specificity | Isoform 2 is expressed in skeletal muscle and brain, and at lower levels in kidney and cardiac muscle. Isoform 2 and isoform 4 are present in skeletal muscle (at protein level). |
| Concentration | 1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol. |
| Purification Method | Protein A purification |
| Research Areas | Cancer, Metabolism, Immunology, Signal Transduction |
| Clone No. | 3B7 |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:1000-2000 |
| IHC | 1:100-200 |
Background
Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues.