Pan Acetyl-Lysine Polyclonal Antibody
SKU: E-AB-40531-200
Pan Acetyl-Lysine Polyclonal Antibody
| SKU # | E-AB-40531 |
| Reactivity | All |
| Host | Rabbit |
| Applications | WB, Dot blot |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | All |
| Applications | WB, Dot blot |
| Clonality | Polyclonal |
| Immunogen | Acetylated Protein |
| Abbre | Pan Acetyl-Lysine |
| Synonyms | Anti-acetyl Lysine, pan acetyl Lysine antibody |
| Concentration | 1 mg/mL |
| Buffer | PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4 |
| Purification Method | Antigen Affinity Purification |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| Purification Method | Antigen Affinity Purification |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:1000-2000 |
| Dot | Blot 1:2000 |
Background
Acetylation is an important modification of proteins in cell biology. Acetylation occurs in thousands of proteins involved in control of cell cycle and metabolism, longevity, actin polymerization, and nuclear transport. In the nucleus, DNA is tightly packed into nucleosomes generating an environment which is highly repressive towards DNA processes such as transcription.The conserved amino-terminal domains of the four core histones (H2A, H2B, H3, and H4) contain lysines that are acetylated by histone acetyltransferases (HATs) and deacetylated by histone deacetylases (HDACs) (1). Signaling resulting in acetylation/deacetylation of histones, transcription factors, and other proteins affects a diverse array of cellular processes including chromatin structure and gene activity, cell growth, differentiation, and apoptosis.