HUS1 Polyclonal Antibody Reactivity Human
SKU: E-AB-52729-200
HUS1 Polyclonal Antibody Reactivity Human
| SKU # | E-AB-52729 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Applications | IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Fusion protein of human HUS1 |
| Abbre | HUS1 |
| Synonyms | S. pombe, homolog of, Checkpoint protein HUS1, HUS1, HUS1 (S. pombe) checkpoint homolog, HUS1 Checkpoint Protein, HUS1 checkpoint homolog (S. pombe), HUS1 protein, HUS1+ - like protein, Hus1, Hydroxyurea-sensitive 1, hHUS1 |
| Swissprot | |
| Cellular Localization | Nucleus. Cytoplasm. In discrete nuclear foci upon DNA damage. According to PubMed:14500360, localized also in the cytoplasm. DNA damage induces its nuclear translocation. Shuttles between the nucleus and the cytoplasm. |
| Concentration | 0.78 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Research Areas | Cancer, Epigenetics and Nuclear Signaling |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| IHC | 1:40-1:200 |
Background
The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage.This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1.In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin.The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event.Alternative splicing results in multiple transcript variants.