HLA-DMB Polyclonal Antibody Reactivity Human
SKU: E-AB-52583-200
HLA-DMB Polyclonal Antibody Reactivity Human
| SKU # | E-AB-52583 |
| Reactivity | Human |
| Host | Rabbit |
| Applications | WB, IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | WB, IHC |
| Clonality | Polyclonal |
| Immunogen | Fusion protein of human HLA-DMB |
| Abbre | HLA-DMB |
| Synonyms | Class II histocompatibility antigen M beta chain, D6S221E, DMB, HLA class II histocompatibility antigen DM beta chain, HLA-DM histocompatibility type, M beta chain, Major histocom, beta chain, class II antigen HLA-DM beta chain, class II histocompatibility antigen |
| Swissprot | |
| Calculated MW | 29 kDa |
| Observed MW | Refer to figures |
| Cellular Localization | Late endosome membrane, Single-pass type I membrane protein, Lysosome membrane, Single-pass type I membrane protein, Note=Localizes to late endocytic compartment, Associates with lysosome membranes. |
| Concentration | 1.38 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Research Areas | Immunology |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| IHC | 1:40-1:200 |
Background
HLA-DMB (Major Histocompatibility Complex, Class II, DM Beta) is a Protein Coding gene. Diseases associated with HLA-DMB include Red-Green Color Blindness and Red Color Blindness. Among its related pathways are ICos-ICosL Pathway in T-Helper Cell and CTLA4 Signaling. GO annotations related to this gene include MHC class II protein complex binding. An important paralog of this gene is ENSG00000248993.HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.