ERCC1 Monoclonal Antibody
SKU: E-AB-22036-200
ERCC1 Monoclonal Antibody
| SKU # | E-AB-22036 |
| Reactivity | Human |
| Host | Mouse |
| Applications | WB |
Product Details
| Isotype | IgG |
| Host | Mouse |
| Reactivity | Human |
| Applications | WB |
| Clonality | Monoclonal |
| Immunogen | Synthetic Peptide |
| Abbre | ERCC1 |
| Synonyms | COFS 4, COFS4, DNA excision repair protein ERCC 1, DNA excision repair protein ERCC-1, DNA excision repair protein ERCC1, ERCC 1, ERCC1, Excision Repair Cross Complementing, Excision repair cross complementation group 1, Excision repair cross complementing 1 |
| Swissprot | |
| Calculated MW | 33 kDa |
| Observed MW | 36 kDa |
| Cellular Localization | Nucleus. |
| Concentration | 1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol. |
| Purification Method | Protein A purification |
| Research Areas | Cancer, Epigenetics and Nuclear Signaling |
| Clone No. | 8K5 |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:1000-1:2000 |
Background
The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand.