WDR77 Polyclonal Antibody Reactivity Human
SKU: E-AB-52236-200
WDR77 Polyclonal Antibody Reactivity Human
| SKU # | E-AB-52236 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Applications | WB |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Applications | WB |
| Clonality | Polyclonal |
| Immunogen | Fusion protein of human WDR77 |
| Abbre | WDR77 |
| Synonyms | 2610312E17Rik, Androgen receptor cofactor p44, C79984, HKMT1069, MEP 50, MEP-50, MEP50, MGC2722, Methylosome protein 50, Nbla10071, RGD1310479 , RP11 552M11.3, WD, WD repeat containing protein 77, WD repeat domain 77 , WD repeat-containing protein 77, p44, p44/Mep50 |
| Swissprot | |
| Calculated MW | 37 kDa |
| Observed MW | Refer to figures |
| Cellular Localization | Nucleus. Cytoplasm. Nuclear in Leydig cells and cytoplasmic in germ cells during fetal testicular development. In adult testis, predominantly nuclear. Subcellular location varies from nuclear to cytoplasmic in various tumors. |
| Concentration | 0.5 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Research Areas | Cancer, Epigenetics and Nuclear Signaling, Signal transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1:2000 |
Background
WDR77 is a component of the 20S PRMT5 (MIM 604045)-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins (see MIM 601061). This modification targets Sm proteins to the survival of motor neurons (SMN) complex (see MIM 600354) for assembly into small nuclear ribonucleoprotein core particles (Friesen et al., 2002 [PubMed 11756452]).